Here is the full list of all 25 The Enchanted Cave 2 achievements.
Completely fill one equipment section of the museum
Complete the main game in a single run
Complete a New Game +
Craft 75 total potions
Defeat the final boss
Craft 15 total potions
Defeat the sorcerer
Complete the combat section of the skill tree
Reach character level 25
Transmute an item
Equip an artifact in every equipment slot
Defeat the Yeti
Save three people
Save two people
Discover 10 secret areas
Save one person
Successfully escape the cave with an artifact
Completely clear one floor of all enemies and loot
Completely fill all sections of the museum
Complete the magic section of the skill tree
Complete the crafting section of the skill tree
Complete the Monster's Lair Challenge
Complete the Labyrinth Challenge
Complete Green Goo's Quest