Full list of all 99 The Binding of Isaac achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 52 achievements, and there are 2 DLC packs containing 47 achievements.
100% the game
Complete the depths without taking damage
Complete Sheol with Cain
Complete the caves without taking damage
Complete Sheol with ???
Complete Sheol with Maggy
Complete the full game with Maggy
Complete the womb without taking damage
Complete the full game with Judas
Complete the full game with ???
Dirty needles... eww
Call death upon all of them!
You defeated Gish!
Complete Sheol with Isaac
Complete the full game 10 times
Complete the basement without taking damage
Complete the full game 8 times
Complete the full game 9 times
Complete Sheol with Eve
Complete the full game 6 times
Complete the full game 7 times
Give mom a taste of her own medicine!
Complete Sheol with Judas
stay out of moms things!
Complete the full game 5 times
Complete the womb with Eve
Complete the full game 4 times
Defeat all bosses in the depths
Complete the full game with Cain
mom needs her pills! donate blood.
Make a Super Meat Boy!
Complete the full game 3 times
Complete the full game 2 times
i lost mine in the arcade...
ive lost my head one too many times...
You defeated C.H.A.D.!
Complete the full game
Destroy the 7 Sins!
Collect 7+ container hearts in one play through
kill mom...
You defeated Steven!
Find Krampus in Satans room for a gift!
Kids shouldnt play with matches...
Make 2 deals with the devil in one play through
Complete the basement
Defeat all bosses in the basement
Complete the Caves
Defeat all bosses in the caves
Kids shouldnt play with dead things...
you dont wanna know where this bean has been...
i like to break things...
Collect 50+ pennies in one play through
???
Complete the final chapter with Samson
Complete the final chapter with Maggy
Complete Challenge 5
Complete Challenge 2
Kill Satan with Samson
Complete the final chapter with Eve
Complete Challenge 9
Complete Challenge 4
Complete the final chapter with Cain
Complete the final chapter with Judas
Complete the final chapter with ???
Complete the final chapter with Isaac
Complete Challenge 1
Complete Challenge 7
Complete Challenge 3
Complete Challenge 8
Kill moms heart with Samson
Complete Challenge 6
Kill mom but pass on 2 treasure room items
100% the game and hardmode (get all the achievements)
Beat the game as Isaac in Hardmode
Beat the game as all characters in Hardmode.
Beat the game as Eve in Hardmode
Beat the game as Samson in Hardmode
Beat the game as ??? in Hardmode, and good luck!
Beat the game as Magdalen in Hardmode
Beat the game as Cain in Hardmode
Beat the Game in Hardmode!
Beat the game as Judas in Hardmode
Beat the boss in the Cathedral in Hardmode
Beat Satan in Hardmode
Gain 7 Health upgrades from Eternal Hearts
Beat Mom in Hardmode
Beat Moms Heart in Hardmode