Here is the full list of all 50 Runers achievements.
Unlock your first secret
Beat Intimidating Difficulty
Defeat The Mind Melter
Defeat The Storm Lord
Defeat The Speedy Bat
Defeat The Elemental Man
Unlock all the extra spell slots
Defeat The Phoenix Matriarch
Reach Level 15
Defeat The Fallen Paladins
Defeat The Storm Brewer
Have a loadout representing every rune type
Defeat The Gooey Globules
Defeat The Chaotic One
Create your first triple combiner
Combine your first triple spell
Defeat The Artist Of The Flames
Beat a room flawlessly
Combine your first double spell
Combine your first rune
Break your first Double Combiner
Break your first Triple Combiner
Defeat The Darkness
Defeat The Earthborn Voidling
Defeat The Maniacal Jester
Defeat The Guardian
Defeat The Anicent Laboratory
Defeat The Shadow Wraith
Defeat The Robot Master
Unlock all secrets
Achieve a Flawless floor
Upgrade the component of a single rune spell to 10
Upgrade all the components of a double rune spell to 10
Upgrade all the components of a triple rune spell to 10
Increase your HP to 150
Have a full loadout of only 1 rune type
Complete the game with at least 95% of your time moving
Complete the game with at most 60% of your time spent moving
Complete The Bestiary
Have each master trait in one runthrough
Complete 25% of the challenges
Complete 50% of the challenges
Complete 75% of the challenges
Complete 100% of the challenges
Beat Apocalpyse Difficulty
Complete The Runedex
Walk into a room with 1 hp and beat the room
Enter a room on floor 10 at max HP and die to the last enemy
Beat the game using only single spells
Beat the game never using your class ability