Here is the full list of all 50 Runers achievements.
Complete the game with at least 95% of your time moving
Beat the game never using your class ability
Defeat The Anicent Laboratory
Have each master trait in one runthrough
Unlock your first secret
Complete the game with at most 60% of your time spent moving
Defeat The Elemental Man
Upgrade all the components of a double rune spell to 10
Increase your HP to 150
Unlock all the extra spell slots
Defeat The Shadow Wraith
Reach Level 15
Upgrade the component of a single rune spell to 10
Defeat The Fallen Paladins
Defeat The Storm Brewer
Defeat The Earthborn Voidling
Walk into a room with 1 hp and beat the room
Defeat The Maniacal Jester
Have a full loadout of only 1 rune type
Achieve a Flawless floor
Complete 50% of the challenges
Defeat The Gooey Globules
Break your first Triple Combiner
Create your first triple combiner
Have a loadout representing every rune type
Defeat The Speedy Bat
Defeat The Artist Of The Flames
Break your first Double Combiner
Combine your first triple spell
Defeat The Chaotic One
Combine your first double spell
Beat a room flawlessly
Combine your first rune
Complete 25% of the challenges
Defeat The Storm Lord
Defeat The Darkness
Defeat The Guardian
Defeat The Phoenix Matriarch
Defeat The Mind Melter
Defeat The Robot Master
Unlock all secrets
Upgrade all the components of a triple rune spell to 10
Complete The Bestiary
Complete 75% of the challenges
Complete 100% of the challenges
Beat Intimidating Difficulty
Beat Apocalpyse Difficulty
Complete The Runedex
Enter a room on floor 10 at max HP and die to the last enemy
Beat the game using only single spells