Here is the full list of all 50 Runers achievements.
Defeat The Artist Of The Flames
Defeat The Speedy Bat
Defeat The Gooey Globules
Defeat The Earthborn Voidling
Have a loadout representing every rune type
Defeat The Storm Brewer
Defeat The Chaotic One
Combine your first triple spell
Create your first triple combiner
Beat a room flawlessly
Break your first Double Combiner
Achieve a Flawless floor
Combine your first rune
Combine your first double spell
Break your first Triple Combiner
Defeat The Storm Lord
Defeat The Darkness
Defeat The Fallen Paladins
Defeat The Maniacal Jester
Defeat The Guardian
Defeat The Phoenix Matriarch
Defeat The Anicent Laboratory
Defeat The Mind Melter
Defeat The Shadow Wraith
Defeat The Elemental Man
Defeat The Robot Master
Unlock your first secret
Unlock all secrets
Upgrade the component of a single rune spell to 10
Upgrade all the components of a double rune spell to 10
Upgrade all the components of a triple rune spell to 10
Increase your HP to 150
Have a full loadout of only 1 rune type
Unlock all the extra spell slots
Complete the game with at least 95% of your time moving
Complete the game with at most 60% of your time spent moving
Complete The Bestiary
Have each master trait in one runthrough
Complete 25% of the challenges
Complete 50% of the challenges
Complete 75% of the challenges
Complete 100% of the challenges
Beat Intimidating Difficulty
Beat Apocalpyse Difficulty
Reach Level 15
Complete The Runedex
Walk into a room with 1 hp and beat the room
Enter a room on floor 10 at max HP and die to the last enemy
Beat the game using only single spells
Beat the game never using your class ability