Here is the full list of all 50 Runers achievements.
Defeat The Speedy Bat
Increase your HP to 150
Defeat The Mind Melter
Break your first Triple Combiner
Defeat The Maniacal Jester
Break your first Double Combiner
Complete 50% of the challenges
Defeat The Gooey Globules
Defeat The Storm Brewer
Defeat The Guardian
Defeat The Elemental Man
Unlock your first secret
Unlock all the extra spell slots
Complete 25% of the challenges
Combine your first rune
Defeat The Chaotic One
Reach Level 15
Have a loadout representing every rune type
Defeat The Artist Of The Flames
Combine your first triple spell
Create your first triple combiner
Beat a room flawlessly
Combine your first double spell
Defeat The Storm Lord
Defeat The Darkness
Defeat The Earthborn Voidling
Defeat The Fallen Paladins
Defeat The Phoenix Matriarch
Defeat The Anicent Laboratory
Defeat The Shadow Wraith
Defeat The Robot Master
Unlock all secrets
Achieve a Flawless floor
Upgrade the component of a single rune spell to 10
Upgrade all the components of a double rune spell to 10
Upgrade all the components of a triple rune spell to 10
Have a full loadout of only 1 rune type
Complete the game with at least 95% of your time moving
Complete the game with at most 60% of your time spent moving
Complete The Bestiary
Have each master trait in one runthrough
Complete 75% of the challenges
Complete 100% of the challenges
Beat Intimidating Difficulty
Beat Apocalpyse Difficulty
Complete The Runedex
Walk into a room with 1 hp and beat the room
Enter a room on floor 10 at max HP and die to the last enemy
Beat the game using only single spells
Beat the game never using your class ability