Full list of all 46 Resident Evil 4 achievements. It takes around 60-80 hours to unlock all of the achievements in the base game on Windows.
The base game contains 39 achievements, and there is 1 DLC pack containing 7 achievements.
Complete the main story on Hardcore mode with an S+ rank.
Complete the main story on Standard mode with an S+ rank.
Obtain all weapons.
Complete the main story on Professional mode.
Earn an S rank in all games at the shooting range.
Complete the main story without using a recovery item.
Complete the main story on Hardcore mode or higher.
Reach the top of the clock tower without the lift stopping once.
Destroy all Clockwork Castellans.
Obtain all treasures indicated on the island treasure map in a single playthrough.
Complete all requests from the Merchant.
Obtain all treasures indicated on the castle treasure map in a single playthrough.
Make it through both minecart sections in the underground tunnel without taking any damage.
Defeat a Garrador using only knives.
Obtain all treasures indicated on the village treasure map in a single playthrough.
Defeat 3 enemies at once with a flash grenade.
Shoot through and destroy 5 targets at the shooting range with a single shot.
Destroy a Clockwork Castellan.
Kill 2 parasites inside a Regenerador with a single bullet.
Sell a single treasure for at least 100000 ptas.
Escape on the water scooter without taking any damage.
Complete the main story within 8 hours.
Complete the main story using only knives and handguns. (Excluding specific battles.)
Complete the main story without talking to the Merchant once.
Throw a grenade into Ramón Salazar's mouth.
Complete the main story on Standard mode or higher.
Defeat Osmund Saddler.
Defeat Jack Krauser.
Get the exclusive upgrade for a weapon.
Defeat Ramón Salazar.
Defeat the Verdugo.
Use a cannon to defeat a zealot.
Defeat Bitores Méndez.
Rescue Ashley as she's being carried away by the enemy.
Complete a request for the Merchant.
Defeat Del Lago.
Complete a game at the shooting range.
Upgrade a weapon.
Parry an enemy with a knife.
Complete Separate Ways on Professional mode with an S+ rank.
Complete Separate Ways on Professional mode.
Complete Separate Ways on Hardcore mode or higher.
Defeat Osmund Saddler in Separate Ways.
Complete Separate Ways on Standard mode or higher.
Defeat Pesanta in Separate Ways.
Defeat El Gigante in Separate Ways.