Full list of all 46 Resident Evil 4 achievements. It takes around 60-80 hours to unlock all of the achievements in the base game on Windows.
The base game contains 39 achievements, and there is 1 DLC pack containing 7 achievements.
Complete all requests from the Merchant.
Earn an S rank in all games at the shooting range.
Shoot through and destroy 5 targets at the shooting range with a single shot.
Kill 2 parasites inside a Regenerador with a single bullet.
Obtain all weapons.
Complete the main story on Standard mode with an S+ rank.
Complete the main story on Hardcore mode with an S+ rank.
Complete the main story on Standard mode or higher.
Complete the main story on Hardcore mode or higher.
Complete the main story on Professional mode.
Complete the main story within 8 hours.
Complete the main story without using a recovery item.
Complete the main story using only knives and handguns. (Excluding specific battles.)
Complete the main story without talking to the Merchant once.
Throw a grenade into Ramón Salazar's mouth.
Obtain all treasures indicated on the castle treasure map in a single playthrough.
Defeat a Garrador using only knives.
Obtain all treasures indicated on the village treasure map in a single playthrough.
Escape on the water scooter without taking any damage.
Destroy all Clockwork Castellans.
Obtain all treasures indicated on the island treasure map in a single playthrough.
Reach the top of the clock tower without the lift stopping once.
Make it through both minecart sections in the underground tunnel without taking any damage.
Sell a single treasure for at least 100000 ptas.
Destroy a Clockwork Castellan.
Defeat Osmund Saddler.
Defeat Jack Krauser.
Defeat Ramón Salazar.
Defeat the Verdugo.
Get the exclusive upgrade for a weapon.
Use a cannon to defeat a zealot.
Defeat 3 enemies at once with a flash grenade.
Defeat Bitores Méndez.
Upgrade a weapon.
Rescue Ashley as she's being carried away by the enemy.
Defeat Del Lago.
Complete a game at the shooting range.
Complete a request for the Merchant.
Parry an enemy with a knife.
Complete Separate Ways on Standard mode or higher.
Complete Separate Ways on Hardcore mode or higher.
Complete Separate Ways on Professional mode.
Complete Separate Ways on Professional mode with an S+ rank.
Defeat Osmund Saddler in Separate Ways.
Defeat Pesanta in Separate Ways.
Defeat El Gigante in Separate Ways.