Here is the full list of all 50 Pathologic 2 achievements. It takes around 0-1 hour to unlock all of the achievements on Windows.
Jump from the Polyhedron
Lock up a shop to preserve a memory
Disperse all Reflections
Watch every pantomime
Witness all dreams—including those you'd rather not
Make a deal with the Fellow Traveler for some relief from death's burden—and find out what it cost you
Face the future with Lara, Grief, and Stakh
Test the new serum on yourself
Return what you didn't deserve
Wait with a friend for the next day to come
Bring something invaluable to the outside world
Be cured of sand plague by touching the Heart of the Town
Repay kindness in kind
Give names to all who are tongue-tied and mute
Hear the Plague's voice
Be late to the ending of your own story
Preserve the Town of humanity and warmth, giving it a future
Finish the game on intended difficulty
Preserve monsters, wonders, and the plague, reviving the past
Wait for the bull to speak
Return to the Town once again
Tick-tock
"Why? What was the purpose of my life?"
Witness the arrival of Alexander Block
Witness another Sky
Find Grace's new home
Touch the thing that produces time
Witness the arrival of Aglaya Lilich
Find a house suffering from an ailment other than sand pest
Save two children from infected houses
Find out if the immortal soul exists
See the Town's history on the walls
Trade with children twenty-seven times
Try your hand at train-summoning
Meet Measly and Thrush in a dream
Hear the alarm bell tolling
Become cursed to remain silent… sometimes
Remind a colleague of the Hippocratic Oath—and fail
Come now, you haven't given us any time to change the set!
Refuse fate—and face the consequences
Feel the flow of time for the first time