Here is the full list of all 50 Pathologic 2 achievements. It takes around 0-1 hour to unlock all of the achievements on Windows.
Jump from the Polyhedron
Make a deal with the Fellow Traveler for some relief from death's burden—and find out what it cost you
Preserve monsters, wonders, and the plague, reviving the past
Finish the game on intended difficulty
Be late to the ending of your own story
Wait with a friend for the next day to come
Test the new serum on yourself
Hear the Plague's voice
Watch every pantomime
Face the future with Lara, Grief, and Stakh
Preserve the Town of humanity and warmth, giving it a future
Wait for the bull to speak
Return to the Town once again
Tick-tock
Disperse all Reflections
Witness all dreams—including those you'd rather not
Give names to all who are tongue-tied and mute
Bring something invaluable to the outside world
Be cured of sand plague by touching the Heart of the Town
Witness the arrival of Alexander Block
Witness another Sky
Find Grace's new home
Touch the thing that produces time
Witness the arrival of Aglaya Lilich
Lock up a shop to preserve a memory
"Why? What was the purpose of my life?"
Save two children from infected houses
Find a house suffering from an ailment other than sand pest
Find out if the immortal soul exists
Trade with children twenty-seven times
Hear the alarm bell tolling
See the Town's history on the walls
Return what you didn't deserve
Become cursed to remain silent… sometimes
Try your hand at train-summoning
Meet Measly and Thrush in a dream
Repay kindness in kind
Come now, you haven't given us any time to change the set!
Remind a colleague of the Hippocratic Oath—and fail
Refuse fate—and face the consequences
Feel the flow of time for the first time