Here is the full list of all 50 Pathologic 2 achievements. It takes around 0-1 hour to unlock all of the achievements on Windows.
Hear the Plague's voice
"Why? What was the purpose of my life?"
Refuse fate—and face the consequences
Finish the game on intended difficulty
Preserve the Town of humanity and warmth, giving it a future
Touch the thing that produces time
Tick-tock
Disperse all Reflections
Bring something invaluable to the outside world
Witness the arrival of Alexander Block
Witness another Sky
Trade with children twenty-seven times
Witness the arrival of Aglaya Lilich
See the Town's history on the walls
Hear the alarm bell tolling
Become cursed to remain silent… sometimes
Feel the flow of time for the first time
Come now, you haven't given us any time to change the set!
Repay kindness in kind
Remind a colleague of the Hippocratic Oath—and fail
Try your hand at train-summoning
Meet Measly and Thrush in a dream
Find a house suffering from an ailment other than sand pest
Return to the Town once again
Witness all dreams—including those you'd rather not
Face the future with Lara, Grief, and Stakh
Jump from the Polyhedron
Find out if the immortal soul exists
Test the new serum on yourself
Give names to all who are tongue-tied and mute
Lock up a shop to preserve a memory
Wait with a friend for the next day to come
Save two children from infected houses
Preserve monsters, wonders, and the plague, reviving the past
Be late to the ending of your own story
Make a deal with the Fellow Traveler for some relief from death's burden—and find out what it cost you
Find Grace's new home
Wait for the bull to speak
Watch every pantomime
Be cured of sand plague by touching the Heart of the Town
Return what you didn't deserve