Here is the full list of all 50 Pathologic 2 achievements. It takes around 0-1 hour to unlock all of the achievements on Windows.
Face the future with Lara, Grief, and Stakh
Preserve the Town of humanity and warmth, giving it a future
Return to the Town once again
Disperse all Reflections
Witness all dreams—including those you'd rather not
Give names to all who are tongue-tied and mute
Be cured of sand plague by touching the Heart of the Town
"Why? What was the purpose of my life?"
Find a house suffering from an ailment other than sand pest
Find out if the immortal soul exists
Meet Measly and Thrush in a dream
Repay kindness in kind
Lock up a shop to preserve a memory
Remind a colleague of the Hippocratic Oath—and fail
Refuse fate—and face the consequences
Make a deal with the Fellow Traveler for some relief from death's burden—and find out what it cost you
Be late to the ending of your own story
Finish the game on intended difficulty
Preserve monsters, wonders, and the plague, reviving the past
Wait for the bull to speak
Watch every pantomime
Tick-tock
Bring something invaluable to the outside world
Witness the arrival of Alexander Block
Jump from the Polyhedron
Witness another Sky
Find Grace's new home
Test the new serum on yourself
Witness the arrival of Aglaya Lilich
Wait with a friend for the next day to come
Trade with children twenty-seven times
Save two children from infected houses
Touch the thing that produces time
See the Town's history on the walls
Try your hand at train-summoning
Hear the alarm bell tolling
Hear the Plague's voice
Return what you didn't deserve
Become cursed to remain silent… sometimes
Come now, you haven't given us any time to change the set!
Feel the flow of time for the first time