Here is the full list of all 50 Pathologic 2 achievements. It takes around 0-1 hour to unlock all of the achievements on Windows.
Find out if the immortal soul exists
Face the future with Lara, Grief, and Stakh
Disperse all Reflections
Make a deal with the Fellow Traveler for some relief from death's burden—and find out what it cost you
Return to the Town once again
Witness all dreams—including those you'd rather not
Be cured of sand plague by touching the Heart of the Town
Jump from the Polyhedron
Find Grace's new home
"Why? What was the purpose of my life?"
Lock up a shop to preserve a memory
Meet Measly and Thrush in a dream
Repay kindness in kind
Try your hand at train-summoning
Remind a colleague of the Hippocratic Oath—and fail
Wait for the bull to speak
Preserve monsters, wonders, and the plague, reviving the past
Give names to all who are tongue-tied and mute
Test the new serum on yourself
Preserve the Town of humanity and warmth, giving it a future
Finish the game on intended difficulty
Be late to the ending of your own story
Bring something invaluable to the outside world
Watch every pantomime
Tick-tock
Witness the arrival of Alexander Block
See the Town's history on the walls
Witness another Sky
Witness the arrival of Aglaya Lilich
Wait with a friend for the next day to come
Find a house suffering from an ailment other than sand pest
Save two children from infected houses
Hear the Plague's voice
Come now, you haven't given us any time to change the set!
Trade with children twenty-seven times
Hear the alarm bell tolling
Return what you didn't deserve
Touch the thing that produces time
Become cursed to remain silent… sometimes
Refuse fate—and face the consequences
Feel the flow of time for the first time