- What Was That Noise?
Using the Black Jack in Deep Storage, clear a room without alerting a single enemy
- Idle Game
Using the Mechanical Doohickey, kill 5 enemies using bullets fired from the Mechanical Doohickey, without moving
- Animal Ally
With Ethereal Rodents, collect a health pickup from Mouse while at critical health
- God-Like Power
With the Font of the Velvet Legion, hold 3000 chips or more
- Vengeance
Defeat the final boss with the L'il Prick in your inventory
- Knight in Shining Cash
With Golden Armor, lose $200 or more cushioning incoming damage
- Engine Of Greed
Complete the game using the Beating Heart of Capitalism (Challenge is valid so long as the item is obtained on the Casino Floor)
- Victory Lap
In Endless Mode, return to the Casino Floor after defeating the final boss
- Show Off
In Endless Mode, return to the Casino Floor after defeating the final boss for a second time
- Winner Winner!
In Endless Mode, achieve a final score of 10 000 points or more
- Chicken Dinner!!!
In Endless Mode, achieve a final score of 50 000 points or more
- Salute The Fallen
In Endless Mode, have 20 or more items break in one run
- Scholar
Collect a Demonology 101 entry
- Demons For Dummies
Collect all of the Demonology 101 entries
- And They Don't Stop Coming
Kill 1000 enemies
- Spent Brass
Fire 1000 or more shots from a single weapon
- A Fair Point
Have an enemy die to a spike trap
- Like Lemmings
Have 3 or more enemies die to a single landmine explosion
- New Toys!
Unlock a new tier of items by defeating a boss
- Full Spectrum
Unlock all items
- Fumble
- Your New Home