Here is the full list of all 50 Loop Hero achievements. It takes around 40-50 hours to unlock all of the achievements on Windows.
Defeat the boss in the first expedition
Defeat Omega 6 times
Place 10 cards you didn't have in your deck, not counting ^Oblivion^
Defeat the hunter 3 times
Die and resurrect 3 times in one expedition
Have 10 living skeletons in one battle
Get all the camp items
Unlock all the encyclopedia
Die outside of battle
Get 10 orange items in exchange for the trophies in camp
Defeat the Priestess 3 times
Kill each enemy
See all the possible tiles
Synthesize 100 resources
Transmute 50 resources into hydrogen
Synthesize 5 resource with alchemy
Transmute 5 resources into hydrogen
Build all the possible camp structures
Defeat Omega
Craft 25 items
Find all possible types of resources
Defeat the Hunter
Dismantle 10 items
Read 50 different dialogues
Defeat the Priestess
Build the river
Embark on your fiftieth expedition
Unlock 50 chapters in the encyclopedia
Unlock a chapter in the encyclopedia
Dismantle 5 items
Unlock the ^Necromancer^ class
Dismantle a camp structure
Defeat the Lich 3 times
Get 5 camp items
Craft 5 items
Die ten times
Complete 100 loops
Lose 100 resources
Drink 50 potions
Embark on your tenth expedition
Place 1000 cards
Unlock the ^Rogue^ class
Fill the whole map
Find 100 resources
Kill 1000 enemies
Defeat the Lich
Build the first camp structure
Die first time
Kill 5 enemies
Embark on your first expedition