Here is the full list of all 50 Loop Hero achievements. It takes around 40-50 hours to unlock all of the achievements on Windows.
Defeat Omega 6 times
Place 10 cards you didn't have in your deck, not counting ^Oblivion^
Get 10 orange items in exchange for the trophies in camp
Defeat the boss in the first expedition
Die outside of battle
Have 10 living skeletons in one battle
Defeat the hunter 3 times
Unlock all the encyclopedia
Get all the camp items
Synthesize 100 resources
Transmute 50 resources into hydrogen
Kill each enemy
Embark on your fiftieth expedition
See all the possible tiles
Synthesize 5 resource with alchemy
Craft 25 items
Transmute 5 resources into hydrogen
Build all the possible camp structures
Defeat Omega
Defeat the Hunter
Dismantle 10 items
Unlock 50 chapters in the encyclopedia
Defeat the Priestess 3 times
Dismantle 5 items
Craft 5 items
Find all possible types of resources
Build the river
Die and resurrect 3 times in one expedition
Read 50 different dialogues
Unlock the ^Necromancer^ class
Defeat the Priestess
Die ten times
Lose 100 resources
Unlock a chapter in the encyclopedia
Dismantle a camp structure
Fill the whole map
Complete 100 loops
Get 5 camp items
Defeat the Lich 3 times
Drink 50 potions
Place 1000 cards
Embark on your tenth expedition
Kill 1000 enemies
Unlock the ^Rogue^ class
Find 100 resources
Embark on your first expedition
Die first time
Kill 5 enemies
Build the first camp structure
Defeat the Lich