Here is the full list of all 50 Leap of Fate achievements.
Finish the game in Hard mode with Aeon.
Clear a level with special kills only.
Complete 72 missions.
Finish the game in Hard mode with Mukai.
Survive the secret Cthulhu card in Hard mode
Finish the game in Normal mode with Big Mo.
Equip each of the 23 glyphs.
Finish the game in Normal mode with Rasimov.
Playing Mukai, finish the game by entering every card of every level (not counting extra cards or the shortcut card)
Finish the game in Normal mode with Mukai.
In a single playthrough, take no damage in a 3-skull combat card. Do this 10 times.
Kill 13 creatures with a single blow.
Upgrade the same glyph twice in a single playthrough.
In a single combat, generate 60 reflected projectiles by shooting at a reflective-aura protected creature.
Finish the game with at least 7 keys, 7 energy cells and 1,500 mana.
Complete level 1.
Complete level 2.
Complete level 3.
Complete level 4.
Complete level 5.
Finish the game in Normal mode with Aeon.
Play with an alternate outfit.
Use a Continue.
Kill 7,500 creatures.
Defeat 1,000 creatures with special kills.
Equip a gold glyph.
Clear every challenge type once.
Accept 30 combat modifiers.
Complete 5 missions.
Complete 20 missions.
Playing Aeon, finish the game by using Shadow Bolt to deal the killing blow on each of the guardians.
Playing Big Mo, finish the game without overheating once.
Playing Rasimov, activate the Immortal ability 6 times and finish the game with full health.
Unlock all of Aeon's permanent upgrades.
Unlock all of Big Mo's permanent upgrades.
Unlock all of Mukai's permanent upgrades.
Unlock all of Rasimov's permanent upgrades.
In a single playthrough, upgrade 6 skills from each of the three skill trees, and equip a gold glyph.
Have 15 health.
In a single playthrough, reroll 3 shops, bypass 2 cards, and cast destiny runes once.
Survive a One-Shot Kill card in which you lost health.
In level 4, be within the range of a doll head's swirl of minions for 20 seconds.
In a single playthrough, purchase 20 items in shops.
Finish the game without purchasing a single skill upgrade.
Finish the game without opening a single locked chest or locked card.
Finish the game without using any glyph.
Finish the game in Hard mode with Big Mo.
Finish the game in Hard mode with Rasimov.
Complete 120 missions.
View every fate in the game.