Here is the full list of all 50 Leap of Fate achievements.
Kill 13 creatures with a single blow.
View every fate in the game.
Playing Rasimov, activate the Immortal ability 6 times and finish the game with full health.
Clear a level with special kills only.
Have 15 health.
Complete 120 missions.
Unlock all of Rasimov's permanent upgrades.
Finish the game without opening a single locked chest or locked card.
In level 4, be within the range of a doll head's swirl of minions for 20 seconds.
Finish the game in Hard mode with Rasimov.
Unlock all of Mukai's permanent upgrades.
In a single playthrough, purchase 20 items in shops.
Unlock all of Big Mo's permanent upgrades.
Finish the game in Hard mode with Mukai.
Finish the game with at least 7 keys, 7 energy cells and 1,500 mana.
Finish the game without purchasing a single skill upgrade.
Finish the game without using any glyph.
In a single playthrough, reroll 3 shops, bypass 2 cards, and cast destiny runes once.
Playing Big Mo, finish the game without overheating once.
Playing Aeon, finish the game by using Shadow Bolt to deal the killing blow on each of the guardians.
Equip each of the 23 glyphs.
Finish the game in Normal mode with Rasimov.
In a single playthrough, upgrade 6 skills from each of the three skill trees, and equip a gold glyph.
Survive a One-Shot Kill card in which you lost health.
Complete 72 missions.
Finish the game in Normal mode with Mukai.
Playing Mukai, finish the game by entering every card of every level (not counting extra cards or the shortcut card)
Finish the game in Hard mode with Aeon.
Unlock all of Aeon's permanent upgrades.
Survive the secret Cthulhu card in Hard mode
Accept 30 combat modifiers.
Finish the game in Hard mode with Big Mo.
Finish the game in Normal mode with Big Mo.
Kill 7,500 creatures.
Upgrade the same glyph twice in a single playthrough.
In a single playthrough, take no damage in a 3-skull combat card. Do this 10 times.
Defeat 1,000 creatures with special kills.
Play with an alternate outfit.
Finish the game in Normal mode with Aeon.
In a single combat, generate 60 reflected projectiles by shooting at a reflective-aura protected creature.
Complete 20 missions.
Clear every challenge type once.
Equip a gold glyph.
Complete level 5.
Complete level 4.
Use a Continue.
Complete level 3.
Complete 5 missions.
Complete level 2.
Complete level 1.