Here is the full list of all 50 Leap of Fate achievements.
Equip each of the 23 glyphs.
Unlock all of Big Mo's permanent upgrades.
Complete 120 missions.
In level 4, be within the range of a doll head's swirl of minions for 20 seconds.
Unlock all of Mukai's permanent upgrades.
View every fate in the game.
Finish the game in Hard mode with Mukai.
Survive a One-Shot Kill card in which you lost health.
Playing Rasimov, activate the Immortal ability 6 times and finish the game with full health.
Unlock all of Rasimov's permanent upgrades.
Finish the game in Hard mode with Rasimov.
Finish the game without purchasing a single skill upgrade.
Finish the game without opening a single locked chest or locked card.
Finish the game without using any glyph.
Playing Mukai, finish the game by entering every card of every level (not counting extra cards or the shortcut card)
Playing Aeon, finish the game by using Shadow Bolt to deal the killing blow on each of the guardians.
In a single playthrough, reroll 3 shops, bypass 2 cards, and cast destiny runes once.
Kill 13 creatures with a single blow.
Finish the game in Hard mode with Big Mo.
Unlock all of Aeon's permanent upgrades.
Finish the game in Hard mode with Aeon.
Survive the secret Cthulhu card in Hard mode
Playing Big Mo, finish the game without overheating once.
Have 15 health.
In a single combat, generate 60 reflected projectiles by shooting at a reflective-aura protected creature.
Accept 30 combat modifiers.
Finish the game in Normal mode with Rasimov.
Finish the game in Normal mode with Mukai.
Complete 72 missions.
Clear a level with special kills only.
Finish the game with at least 7 keys, 7 energy cells and 1,500 mana.
Kill 7,500 creatures.
Finish the game in Normal mode with Aeon.
In a single playthrough, take no damage in a 3-skull combat card. Do this 10 times.
In a single playthrough, purchase 20 items in shops.
Play with an alternate outfit.
Clear every challenge type once.
In a single playthrough, upgrade 6 skills from each of the three skill trees, and equip a gold glyph.
Defeat 1,000 creatures with special kills.
Complete 20 missions.
Finish the game in Normal mode with Big Mo.
Complete level 5.
Upgrade the same glyph twice in a single playthrough.
Equip a gold glyph.
Complete level 4.
Complete 5 missions.
Complete level 3.
Use a Continue.
Complete level 2.
Complete level 1.