Here is the full list of all 48 Iesabel achievements.
Complete Iesabel on easy difficulty mode
Talk through every dialogue in the game. No skipping
Max a least one characteristic
Gather a total of 150.000 gold
Have an epic/unique/legendary item equipped in every slot
Reach the 44th level
Open 100 chests
Kill 666 skeletons
Use 150 potions
Collect 500 orbs
Kill 2 500 foes
Sell objects worth 25 000 gold
Max a passive skill
Reach the 33rd level
Find all stone portals
Identify 15 items
Reach the 22nd level
Open 30 chests
Plunder 30 bodies
Collect 100 orbs
Reach the 11th level
Reach the 55th level
Reach the 66th level
Complete Iesabel on medium difficulty mode
Complete Iesabel on hard difficulty mode
Craft and enchant any rune
Max an active skill
Complete Act 2 with running toggled off
Kill the Black Widow without receiving damage
Complete a location killing all the enemies and not losing any health
Complete all quests
Join a multiplayer game
Complete the game in co-op
Host 30 servers total
Play a 5-player game
Watch the credits
Kill any boss while having <10% HP
Don't use Amulet of life-saving throughout the entire game
Gather a total of 500.000 gold
Destroy 30 barrels
Destroy 100 barrels
Plunder 100 bodies
Kill 7 500 foes
Kill 20 000 foes
Kill 50 000 foes
Kill 100 000 foes
Sell objects worth 100 000 gold
Get killed 100 times