Here is the full list of all 48 Iesabel achievements.
Watch the credits
Complete Iesabel on easy difficulty mode
Don't use Amulet of life-saving throughout the entire game
Have an epic/unique/legendary item equipped in every slot
Plunder 100 bodies
Kill 7 500 foes
Gather a total of 150.000 gold
Reach the 44th level
Sell objects worth 25 000 gold
Complete Act 2 with running toggled off
Open 100 chests
Kill 666 skeletons
Reach the 33rd level
Find all stone portals
Complete a location killing all the enemies and not losing any health
Collect 500 orbs
Reach the 22nd level
Kill 2 500 foes
Max a passive skill
Open 30 chests
Plunder 30 bodies
Reach the 11th level
Collect 100 orbs
Identify 15 items
Max a least one characteristic
Reach the 55th level
Reach the 66th level
Complete Iesabel on medium difficulty mode
Complete Iesabel on hard difficulty mode
Craft and enchant any rune
Max an active skill
Kill the Black Widow without receiving damage
Complete all quests
Join a multiplayer game
Complete the game in co-op
Host 30 servers total
Play a 5-player game
Talk through every dialogue in the game. No skipping
Kill any boss while having <10% HP
Gather a total of 500.000 gold
Destroy 30 barrels
Destroy 100 barrels
Kill 20 000 foes
Kill 50 000 foes
Kill 100 000 foes
Sell objects worth 100 000 gold
Use 150 potions
Get killed 100 times