Here is the full list of all 48 Iesabel achievements.
Complete Iesabel on easy difficulty mode
Don't use Amulet of life-saving throughout the entire game
Talk through every dialogue in the game. No skipping
Max an active skill
Plunder 100 bodies
Max a least one characteristic
Reach the 44th level
Max a passive skill
Gather a total of 150.000 gold
Open 100 chests
Kill 666 skeletons
Reach the 33rd level
Use 150 potions
Kill 2 500 foes
Collect 500 orbs
Identify 15 items
Find all stone portals
Reach the 22nd level
Watch the credits
Open 30 chests
Plunder 30 bodies
Kill any boss while having <10% HP
Reach the 11th level
Collect 100 orbs
Reach the 55th level
Reach the 66th level
Have an epic/unique/legendary item equipped in every slot
Complete Iesabel on medium difficulty mode
Complete Iesabel on hard difficulty mode
Craft and enchant any rune
Complete Act 2 with running toggled off
Kill the Black Widow without receiving damage
Complete a location killing all the enemies and not losing any health
Complete all quests
Join a multiplayer game
Complete the game in co-op
Host 30 servers total
Play a 5-player game
Gather a total of 500.000 gold
Destroy 30 barrels
Destroy 100 barrels
Kill 7 500 foes
Kill 20 000 foes
Kill 50 000 foes
Kill 100 000 foes
Sell objects worth 25 000 gold
Sell objects worth 100 000 gold
Get killed 100 times