Here is the full list of all 48 Iesabel achievements.
Reach the 66th level
Gather a total of 500.000 gold
Craft and enchant any rune
Reach the 55th level
Max a passive skill
Have an epic/unique/legendary item equipped in every slot
Watch the credits
Complete Iesabel on easy difficulty mode
Don't use Amulet of life-saving throughout the entire game
Gather a total of 150.000 gold
Plunder 100 bodies
Reach the 44th level
Complete Act 2 with running toggled off
Kill 666 skeletons
Open 100 chests
Sell objects worth 25 000 gold
Kill 2 500 foes
Collect 500 orbs
Kill any boss while having <10% HP
Use 150 potions
Reach the 33rd level
Find all stone portals
Identify 15 items
Reach the 22nd level
Open 30 chests
Plunder 30 bodies
Collect 100 orbs
Reach the 11th level
Complete Iesabel on medium difficulty mode
Complete Iesabel on hard difficulty mode
Max an active skill
Max a least one characteristic
Kill the Black Widow without receiving damage
Complete a location killing all the enemies and not losing any health
Complete all quests
Join a multiplayer game
Complete the game in co-op
Host 30 servers total
Play a 5-player game
Talk through every dialogue in the game. No skipping
Destroy 30 barrels
Destroy 100 barrels
Kill 7 500 foes
Kill 20 000 foes
Kill 50 000 foes
Kill 100 000 foes
Sell objects worth 100 000 gold
Get killed 100 times