Here is the full list of all 48 Iesabel achievements.
Kill 7 500 foes
Reach the 66th level
Gather a total of 500.000 gold
Have an epic/unique/legendary item equipped in every slot
Sell objects worth 100 000 gold
Craft and enchant any rune
Max an active skill
Reach the 55th level
Complete Iesabel on easy difficulty mode
Gather a total of 150.000 gold
Plunder 100 bodies
Reach the 44th level
Max a least one characteristic
Open 100 chests
Kill 666 skeletons
Reach the 33rd level
Sell objects worth 25 000 gold
Find all stone portals
Join a multiplayer game
Use 150 potions
Kill 2 500 foes
Collect 500 orbs
Identify 15 items
Reach the 22nd level
Max a passive skill
Open 30 chests
Plunder 30 bodies
Reach the 11th level
Collect 100 orbs
Watch the credits
Complete Iesabel on medium difficulty mode
Complete Iesabel on hard difficulty mode
Complete Act 2 with running toggled off
Kill the Black Widow without receiving damage
Complete a location killing all the enemies and not losing any health
Complete all quests
Complete the game in co-op
Host 30 servers total
Play a 5-player game
Talk through every dialogue in the game. No skipping
Kill any boss while having <10% HP
Don't use Amulet of life-saving throughout the entire game
Destroy 30 barrels
Destroy 100 barrels
Kill 20 000 foes
Kill 50 000 foes
Kill 100 000 foes
Get killed 100 times