Here is the full list of all 20 Duke Nukem 3D: Megaton Edition achievements. It takes around 10-12 hours to unlock all of the achievements on Windows.
Earn respect and get 500 total kills in Dukematch games (Online)
Complete "Duke: Nuclear Winter" on any difficulty
Complete "The Birth" on any difficulty
Find Luke Skywalker on "Lunar Reactor" level
Get 250 total kills in Dukematch games (Online)
Complete "Shrapnel City" on any difficulty
Get 100 total kills in Dukematch games (Online)
Complete "Duke Caribbean: Life's A Beach" on any difficulty
Find 70 secret areas
Complete "Lunar Apocalypse" on any difficulty
Kill 1000 enemies
Step in a pile of excrement
Complete "Duke It Out In D.C." on any difficulty
Kill every enemy on a level
Finish the "Hollywood Holocaust" level in under 3 minutes
Complete "L.A. Meltdown" on any difficulty
Step on 40 enemies after using the Shrinker on them
Find the Doomguy on "Death Row" level
Tip an exotic dancer
Use a cheat code