Here is the full list of all 50 Core Defense achievements.
Get the same upgrade ten times.
Get a rare core module.
Get a rare upgrade.
Beat a boss.
Install a core module.
Get the same upgrade twice.
Beat a wave without taking core damage.
Defeat at least seven bosses in one run.
Get a rare tower.
Get a rare ability.
Beat the game with exactly one tower and without abilities.
Beat the game with seven towers.
Beat the game without taking core damage.
Beat the game on difficulty "Hard".
Beat the game on difficulty "Overload 5".
Beat the game on difficulty "Overload 10".
Beat the game on difficulty "Overload 15".
Beat the game on difficulty "Overload 20".
Get the same upgrade 25 times.
Get 10 extra walls.
Get 25 extra walls.
Get 50 extra walls.
Unlock all rewards.
Discover everything in the compendium.
Beat the game without core modules.
Beat the game with 40 or more rares.
Beat the game without rares.
Beat the game without uncommon or rare rewards.
Beat the game without losing a tower.
Beat the game without letting a mob escape.
Beat the game without healing towers or abilities.
Beat the game without killing a single mob.
Finish a wave with a fully shielded Core.
Beat the game without additional walls.
Beat the game without common rewards.
Beat the game after skipping 50 rewards.
Deal more than 1000 damage with one shot.
Unlock all other achievements.
Defeat 100 waves in endless mode.
Win 10 runs in a row.
Win 5 runs in a row on Overload 10 or higher.
Win 2 runs in a row on the highest difficulty.
Win a run in under 10 minutes
Reach the maximum level.
Beat the game on difficulty Overload 25.
Beat each supercharge modifier once.
Finish a daily run.
Finish a daily run with a score of at least 5000.
Beat Overload 25 without masteries.
Beat the game on difficulty Overload 30.