You can unlock the achievement right after finishing the tutorial. If you have a save with more progress, you can just start a new game quickly to grab it without affecting your main playthrough.
The easiest recipe for this is to craft the Cure Disease potion using:
Cure (L1 Life) + Cure (L1 Life).
Here's all you need to do:
- Buy 2x Coal from the shop.
- Chop the 2x Coal on the Cutting Board while activating the Heat-Cold to remove the fire element.
- Toss the chopped coal into the Cauldron and mix it.