Here is a YouTube link to a video guide made by
nekov4ego. I found it very helpful for completing the Tough Guy achievement. On YouTube,
nekov4ego provides a summary below the video.
During my playthrough, I made some changes to make things easier for myself. nekov4ego left a lot of ADAM unspent, but I spent some on engineering tonics in order to hack the Circus Value vending machine to get cheaper prices on first-aid kits and EVE hypos.
Below is a breakdown of every plasmid and tonic I purchased after which rooms and when the hack occurred:
A SINGLE SPLICER—combat tonics: damage research, wrench jockey
A SINGLE BIG DADDY—plasmid: electric bolt 3
HOUDINI SPLICERS—combat tonic: armored shell & physical tonic: eve saver
SPIDER SPLICERS—engineering tonics: focused hacker, speedy hacker 2 &
vending machine hackSECURITY TURRET MAZE—plasmid: target dummy
ALL KINDS OF ENEMIES—n/a
SECURITY BOTS—plasmid: incinerate 2
BIG DADDIES—n/a