This took me a lot of atempts, enemies in the depths are the hardest to take no damage from in my opinion, some rooms are unfair as well trowing large amount of enemies at you with limited space. You just got to get lucky with rng and focus on items that will increase your survavibility, like:
- Items that make you fly
- Items that give you short invincibility (e.g. Book of shadows)
- Damage and tears increasing items just to kill enemies quicker
- Speed boosting items to dodge easier
In my winning attempt i picked isaac, and rerolled any weak items and hp up's, beacause they are ussles for you. Don't be scared of devil deals too.