Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
Unlocked a new co-player baby.
Beat caves without taking damage.
Donated 600 pennies to the shop.
Built him out of meat cubes.
OMG!
Beat Chest or Dark Room without taking damage.
Beat depths without taking damage.
Unlocked Challenge #11.
New boss in the womb!
You are the best!!
Beat womb without taking damage.
Unlocked Challenge #8.
Unlocked another miniboss!
Isaac now holds the D6!
Unlocked Challenge #19.
Donated 200 pennies to the shop.
They are waiting.
You became Lord of the Flies.
Unlocked a new boss!
New boss in the caves!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
New boss in the depths!
Unlocked Challenge #9.
New boss in the basement!
Donated 100 pennies to the shop.
The game just got harder!
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked Challenge #6.
Destroy 100 rocks.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Donated 20 pennies to the shop.
Beat basement without taking damage.
111% now stop playing!
Unlocked a new starting item.
Nerd x 1000000
Unlocked a new item
Greed just got harder!
Unlocked a secret.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked...
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Make a new friend!
Beat everything in Hard mode with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Bethany.
Obtain 99 pennies. Then spend every single one of them.
Complete the final chapter with the Forgotten.
Complete the Corpse with the Forgotten.
Complete the final chapter with Apollyon.
Complete the Corpse with Apollyon.
Complete the Corpse with Keeper.
Kill 10 Battery Bums.
Complete the Corpse with Eden.
Complete the final chapter with Keeper.
Complete the final chapter with Lilith.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Complete the final chapter with Eden.
Complete the final chapter with Azazel.
Complete the final chapter with ???.
Complete the final chapter with Cain.
Complete the final chapter with Isaac.
Kill Hornfel before he escapes!
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with Lazarus.
Complete the final chapter with Samson.
Complete the final chapter with Eve.
Complete the final chapter with Judas.
Complete the final chapter with Magdalene.
Beat Greedier mode with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Kids shouldn't believe in fortunes...
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Defeat Baby Plum 10 times.
The other side is calling...
You are just like your father...
Complete the Corpse with Isaac.
Complete the Corpse with Lilith.
Where could it lead to?
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Get that song out of her head.
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Spend 40+ pennies in a single shop.
Complete ??? 3 times.
Complete the Cathedral with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Magdalene.
Complete the Corpse with Cain.
Complete the Corpse with Judas.
Complete the Corpse with ???.
Complete the Corpse with Eve.
Complete the Corpse with Samson.
Complete the Corpse with Azazel.
Complete the Corpse with Lazarus.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
They will charge you up... for a small fee.
Beat everything in Hard Mode as every character.