Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Beat Chest or Dark Room without taking damage.
Donated 600 pennies to the shop.
Unlocked a new character.
New mode unlocked!
Unlocked a new co-player baby.
Unlocked new enemies!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
OMG!
Built him out of meat cubes.
You are the best!!
Unlocked Challenge #19.
Unlocked a new boss!
New boss in the womb!
Beat womb without taking damage.
Donated 200 pennies to the shop.
They are waiting.
You became Lord of the Flies.
Isaac now holds the D6!
New boss in the caves!
New boss in the depths!
New boss in the basement!
Unlocked Challenge #8.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #9.
Beat depths without taking damage.
The game just got harder!
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked Challenge #6.
Donated 100 pennies to the shop.
Unlocked another miniboss!
Beat caves without taking damage.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Destroy 100 rocks.
Donated 20 pennies to the shop.
Beat basement without taking damage.
111% now stop playing!
Unlocked Challenge #11.
Unlocked a new item
Unlocked a new starting item.
Nerd x 1000000
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked...
Unlocked a new challenge.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked super special rocks.
Complete the Corpse with ???.
Complete the Corpse with Lazarus.
Complete the Void with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with Bethany.
Defeat all bosses in the Mines.
Kill 10 Battery Bums.
Complete the final chapter with Cain.
Get that song out of her head.
Defeat Baby Plum 10 times.
Complete the final chapter with Azazel.
The other side is calling...
Defeat all bosses in the Mausoleum.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Defeat all bosses in Downpour.
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Enter the Corpse...
Kill Hornfel before he escapes!
Complete ??? 3 times.
Kids shouldn't believe in fortunes...
Obtain 99 pennies. Then spend every single one of them.
Spend 40+ pennies in a single shop.
Make a new friend!
Complete the Cathedral with Bethany.
Complete Sheol with Bethany.
Complete the Chest with Bethany.
Complete the Dark Room with Bethany.
Complete Boss Rush with Bethany.
Beat Greed mode with Bethany.
Complete ??? with Bethany.
Beat Greedier mode with Bethany.
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Defeat Mega Satan with Bethany.
Complete Sheol with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Isaac.
Complete the final chapter with Isaac.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Complete the Corpse with Cain.
Complete the Corpse with Judas.
Complete the final chapter with Judas.
Complete the final chapter with ???.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the final chapter with Lazarus.
Complete the Corpse with Eden.
Complete the final chapter with Eden.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the final chapter with Bethany.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
They will charge you up... for a small fee.
Beat everything in Hard Mode as every character.