Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
Unlocked a new co-player baby.
Beat Chest or Dark Room without taking damage.
You became Lord of the Flies.
Built him out of meat cubes.
OMG!
Donated 600 pennies to the shop.
You are the best!!
Beat womb without taking damage.
Isaac now holds the D6!
New boss in the womb!
Unlocked another miniboss!
Unlocked Challenge #11.
Unlocked Challenge #19.
New boss in the basement!
They are waiting.
New boss in the caves!
Unlocked a new boss!
New boss in the depths!
Donated 200 pennies to the shop.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Beat caves without taking damage.
Unlocked Challenge #9.
Beat depths without taking damage.
Unlocked Challenge #8.
Donated 100 pennies to the shop.
The game just got harder!
Unlocked Challenge #6.
Beat basement without taking damage.
Donated 20 pennies to the shop.
Destroy 100 rocks.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Unlocked Challenge #5.
Unlocked Challenge #10.
111% now stop playing!
Nerd x 1000000
Unlocked a new starting item.
Unlocked a secret.
Unlocked a new item
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked...
Unlocked super special rocks.
Unlocked a new challenge.
Unlocked a new area.
Unlocked the power of RERUN.
Complete the Corpse with Lilith.
Complete the Corpse with Lazarus.
Complete the Corpse with Eden.
Complete the final chapter with Lazarus.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat Greedier mode with Bethany.
Beat the game in Hard mode with Jacob and Esau.
Complete the Corpse with the Forgotten.
Complete the final chapter with Isaac.
Complete the Corpse with Eve.
Obtain 99 pennies. Then spend every single one of them.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat the Void with Bethany.
Complete ??? with Bethany.
Beat the game in Hard mode with Bethany.
Complete the Corpse with Isaac.
Beat Greed mode with Bethany.
Spend 40+ pennies in a single shop.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete Boss Rush with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat Hard mode as Lazarus without losing a life
Complete the final chapter with Azazel.
Complete the Corpse with Azazel.
Defeat Baby Plum 10 times.
Get that song out of her head.
The other side is calling...
Complete the Corpse with Apollyon.
Complete the Corpse with Judas.
You are just like your father...
Complete the Corpse with Samson.
Where could it lead to?
Kids shouldn't believe in fortunes...
Enter the Corpse...
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Defeat all bosses in the Mausoleum.
Defeat all bosses in Downpour.
Complete ??? 3 times.
Make a new friend!
Beat everything in Hard mode with Bethany.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Complete the Corpse with Cain.
Complete the final chapter with Cain.
Complete the final chapter with Judas.
Complete the Corpse with ???.
Complete the final chapter with ???.
Complete the final chapter with Eve.
Complete the final chapter with Samson.
Complete the final chapter with Eden.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the final chapter with Lilith.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the final chapter with Apollyon.
Complete the final chapter with the Forgotten.
Complete the Corpse with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
They will charge you up... for a small fee.
Kill 10 Battery Bums.
Beat everything in Hard Mode as every character.