Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Beat caves without taking damage.
Beat depths without taking damage.
Unlocked a new character.
New mode unlocked!
Unlocked even more bosses!
Donated 600 pennies to the shop.
Unlocked new enemies!
Alt stage to the womb.
Unlocked new bosses!
Alt stage to the depths.
Alt stage to the caves.
Beat womb without taking damage.
Alt stage to the basement.
Unlocked a new co-player baby.
Beat Chest or Dark Room without taking damage.
Unlocked Challenge #19.
You are the best!!
New boss in the womb!
You became Lord of the Flies.
They are waiting.
Isaac now holds the D6!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Donated 200 pennies to the shop.
Unlocked Challenge #9.
Unlocked a new boss!
The game just got harder!
New boss in the depths!
Unlocked Challenge #6.
New boss in the caves!
Unlocked Challenge #8.
Unlocked another miniboss!
Donated 100 pennies to the shop.
New boss in the basement!
Donated 20 pennies to the shop.
Beat basement without taking damage.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
OMG!
111% now stop playing!
Built him out of meat cubes.
Unlocked Challenge #11.
Unlocked Challenge #26.
Unlocked a new starting item.
Unlocked Challenge #24.
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked a new item
Unlocked...
Nerd x 1000000
Unlocked a new challenge.
Unlocked a new area.
Unlocked super special rocks.
Unlocked the power of RERUN.
Complete the final chapter with Bethany.
Complete the final chapter with Samson.
The other side is calling...
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Kill Hornfel before he escapes!
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Beat Greedier mode with Bethany.
Obtain 99 pennies. Then spend every single one of them.
Kids shouldn't believe in fortunes...
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Get that song out of her head.
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Beat Greed mode with Bethany.
Complete ??? 3 times.
Complete Sheol with Bethany.
Spend 40+ pennies in a single shop.
Complete the Cathedral with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Make a new friend!
Defeat Baby Plum 10 times.
Beat Hard mode as Lazarus without losing a life
Beat the game in Hard mode with Bethany.
Complete the Dark Room with Bethany.
Beat everything in Hard mode with Bethany.
Beat the game in Hard mode with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the final chapter with Isaac.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Complete the Corpse with Cain.
Complete the final chapter with Cain.
Complete the Corpse with Judas.
Complete the final chapter with Judas.
Complete the Corpse with ???.
Complete the final chapter with ???.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with Samson.
Complete the Corpse with Azazel.
Complete the final chapter with Azazel.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Complete the Corpse with Eden.
Complete the final chapter with Eden.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the Corpse with Bethany.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
They will charge you up... for a small fee.
Kill 10 Battery Bums.
Beat everything in Hard Mode as every character.