Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
OMG!
111% now stop playing!
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
Unlocked a new co-player baby.
Unlocked Challenge #11.
New boss in the womb!
Beat womb without taking damage.
Donated 200 pennies to the shop.
Donated 600 pennies to the shop.
Beat caves without taking damage.
Built him out of meat cubes.
You are the best!!
New boss in the caves!
New boss in the basement!
Isaac now holds the D6!
Beat basement without taking damage.
Unlocked a new boss!
New boss in the depths!
Beat depths without taking damage.
Unlocked Challenge #19.
Beat Chest or Dark Room without taking damage.
They are waiting.
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
Donated 100 pennies to the shop.
Unlocked Challenge #9.
Unlocked another miniboss!
The game just got harder!
Unlocked Challenge #8.
Donated 20 pennies to the shop.
Unlocked Challenge #6.
You became Lord of the Flies.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Destroy 100 rocks.
Unlocked Challenge #5.
Unlocked Challenge #10.
Nerd x 1000000
Unlocked a new item
Unlocked...
Unlocked Challenge #24.
Unlocked a new starting item.
Greed just got harder!
Unlocked a secret.
Unlocked Challenge #27.
Unlocked Challenge #26.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked a new area.
Unlocked the power of RERUN.
Unlocked a new challenge.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Corpse with Cain.
Kill Hornfel before he escapes!
Kill 10 Battery Bums.
Complete the final chapter with Keeper.
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Complete the Corpse with the Lost.
Complete the final chapter with Apollyon.
Complete the Corpse with Eden.
Complete the final chapter with Azazel.
Beat Greedier mode with Bethany.
Beat Greed mode with Bethany.
Complete the final chapter with Bethany.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Complete the Void with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the final chapter with Lazarus.
Complete the final chapter with ???.
Complete the final chapter with Lilith.
Complete the final chapter with Eve.
Complete the final chapter with Magdalene.
They will charge you up... for a small fee.
Complete the final chapter with Samson.
Complete the final chapter with the Lost.
Complete the Corpse with Judas.
Complete the final chapter with Cain.
Complete the final chapter with Isaac.
Complete the Corpse with Bethany.
Defeat Baby Plum 10 times.
Complete the Corpse with Apollyon.
Complete Sheol with Bethany.
Complete the final chapter with Eden.
Obtain 99 pennies. Then spend every single one of them.
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Complete the final chapter with Judas.
The other side is calling...
Spend 40+ pennies in a single shop.
You are just like your father...
Where could it lead to?
Complete the Corpse with Isaac.
Enter the Corpse...
Get that song out of her head.
Kids shouldn't believe in fortunes...
Defeat all bosses in Downpour.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.
Make a new friend!
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Magdalene.
Complete the Corpse with ???.
Complete the Corpse with Eve.
Complete the Corpse with Samson.
Complete the Corpse with Azazel.
Complete the Corpse with Lazarus.
Complete the Corpse with Lilith.
Complete the Corpse with Keeper.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the Corpse with Jacob and Esau.
Beat everything in Hard Mode as every character.