Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
OMG!
111% now stop playing!
Built him out of meat cubes.
Unlocked a new co-player baby.
Unlocked Challenge #11.
New boss in the womb!
Isaac now holds the D6!
You are the best!!
Donated 600 pennies to the shop.
Unlocked Challenge #19.
You became Lord of the Flies.
Beat Chest or Dark Room without taking damage.
Beat caves without taking damage.
They are waiting.
Beat womb without taking damage.
Unlocked a new boss!
New boss in the caves!
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
Donated 200 pennies to the shop.
Unlocked Challenge #9.
New boss in the basement!
Unlocked another miniboss!
New boss in the depths!
Beat depths without taking damage.
The game just got harder!
Donated 100 pennies to the shop.
Unlocked Challenge #6.
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked Challenge #8.
Beat basement without taking damage.
Donated 20 pennies to the shop.
Destroy 100 rocks.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Nerd x 1000000
Unlocked a new starting item.
Unlocked...
Greed just got harder!
Unlocked a secret.
Unlocked a new item
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
Complete the Corpse with the Lost.
Beat everything in Hard Mode as every character.
Complete the Corpse with Keeper.
Complete the final chapter with the Lost.
Complete the final chapter with Keeper.
Beat everything in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Complete the Void with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the Corpse with Bethany.
Complete the Corpse with Lilith.
Complete the final chapter with Eden.
They will charge you up... for a small fee.
Obtain 99 pennies. Then spend every single one of them.
Complete the Corpse with Eve.
Complete the Corpse with ???.
Complete the Corpse with Lazarus.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Magdalene.
Complete the final chapter with Lilith.
Complete the Corpse with Eden.
Complete the final chapter with Magdalene.
Complete the Corpse with Cain.
Complete the Corpse with Samson.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Judas.
Complete the final chapter with Apollyon.
Complete the final chapter with Samson.
Kill 10 Battery Bums.
Complete the Corpse with Judas.
Complete the Corpse with the Forgotten.
Complete the final chapter with Azazel.
Complete the Corpse with Apollyon.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat the Void with Bethany.
Complete ??? with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat Greedier mode with Bethany.
Beat Greed mode with Bethany.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the final chapter with ???.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete ??? with Bethany.
Beat the game in Hard mode with Bethany.
Complete the final chapter with Lazarus.
Defeat Baby Plum 10 times.
Kids shouldn't believe in fortunes...
Complete the final chapter with Eve.
Complete the final chapter with the Forgotten.
Complete the final chapter with Cain.
Complete the Corpse with Isaac.
Spend 40+ pennies in a single shop.
Make a new friend!
Complete the final chapter with Isaac.
The other side is calling...
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Enter the Corpse...
Get that song out of her head.
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.