Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
111% now stop playing!
OMG!
Unlocked a new co-player baby.
Donated 600 pennies to the shop.
Beat depths without taking damage.
Built him out of meat cubes.
Unlocked Challenge #11.
Unlocked Challenge #19.
New boss in the womb!
You are the best!!
Beat Chest or Dark Room without taking damage.
Beat womb without taking damage.
They are waiting.
You became Lord of the Flies.
Unlocked a new boss!
Isaac now holds the D6!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #9.
New boss in the caves!
Beat caves without taking damage.
New boss in the basement!
Donated 200 pennies to the shop.
New boss in the depths!
The game just got harder!
Donated 100 pennies to the shop.
Unlocked Challenge #6.
Unlocked another miniboss!
Unlocked Challenge #8.
Donated 20 pennies to the shop.
Destroy 100 rocks.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Beat basement without taking damage.
Unlocked Challenge #5.
Unlocked Challenge #10.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a secret.
Greed just got harder!
Unlocked a new item
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
They will charge you up... for a small fee.
Beat everything in Hard mode with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Beat everything in Hard Mode as every character.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Bethany.
Complete the Corpse with the Forgotten.
Complete the Corpse with Apollyon.
Complete the Corpse with Keeper.
Complete the Corpse with Lilith.
Complete the Corpse with the Lost.
Complete the Corpse with Eden.
Complete the Corpse with Lazarus.
Complete the Corpse with Samson.
Complete the Corpse with Eve.
Complete the Corpse with ???.
Complete the Corpse with Judas.
Kill 10 Battery Bums.
Complete the Corpse with Cain.
Complete the final chapter with Jacob and Esau.
Complete the final chapter with Bethany.
Complete the final chapter with the Forgotten.
Complete the final chapter with Apollyon.
Complete the final chapter with Keeper.
Complete the final chapter with Eden.
Complete the final chapter with Lazarus.
Complete the final chapter with the Lost.
Complete the Corpse with Magdalene.
Complete the final chapter with Samson.
Complete the final chapter with Eve.
Complete the final chapter with ???.
Complete the final chapter with Judas.
Complete the final chapter with Magdalene.
Complete the Void with Jacob and Esau.
Complete the Corpse with Isaac.
Complete the final chapter with Isaac.
Defeat Mega Satan with Jacob and Esau.
Complete ??? with Jacob and Esau.
Kids shouldn't believe in fortunes...
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Obtain 99 pennies. Then spend every single one of them.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat the Void with Bethany.
Complete Boss Rush with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Defeat Mega Satan with Bethany.
Complete ??? with Bethany.
Complete the final chapter with Lilith.
Beat Greedier mode with Bethany.
Complete the Chest with Bethany.
Get that song out of her head.
Complete the final chapter with Cain.
Make a new friend!
Complete the final chapter with Azazel.
Spend 40+ pennies in a single shop.
Defeat Baby Plum 10 times.
The other side is calling...
Beat Greed mode with Bethany.
You are just like your father...
Where could it lead to?
Complete the Corpse with Azazel.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Enter the Corpse...
Kill Hornfel before he escapes!
Complete ??? 3 times.