Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
OMG!
111% now stop playing!
Donated 600 pennies to the shop.
Unlocked a new co-player baby.
Unlocked Challenge #11.
Built him out of meat cubes.
Beat depths without taking damage.
Isaac now holds the D6!
New boss in the womb!
Beat Chest or Dark Room without taking damage.
Unlocked Challenge #19.
You became Lord of the Flies.
You are the best!!
Unlocked Challenge #8.
They are waiting.
New boss in the caves!
New boss in the basement!
Beat womb without taking damage.
Donated 200 pennies to the shop.
Unlocked a new boss!
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
Unlocked another miniboss!
Unlocked Challenge #9.
New boss in the depths!
Donated 100 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
The game just got harder!
Beat caves without taking damage.
Unlocked Challenge #6.
Beat basement without taking damage.
Donated 20 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Destroy 100 rocks.
Unlocked Challenge #20.
Unlocked a new starting item.
Nerd x 1000000
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked...
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Lazarus.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with the Lost.
Complete the Corpse with Eve.
Kill 10 Battery Bums.
Complete the Corpse with ???.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the Corpse with Eden.
Complete the Corpse with the Forgotten.
Beat the Void with Bethany.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the final chapter with Eden.
Complete the final chapter with the Lost.
Complete the Corpse with Apollyon.
Beat the game in Hard mode with Bethany.
Complete Boss Rush with Bethany.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with Bethany.
Complete the final chapter with Jacob and Esau.
Complete the final chapter with Lazarus.
Obtain 99 pennies. Then spend every single one of them.
Complete the final chapter with Apollyon.
They will charge you up... for a small fee.
Complete the final chapter with ???.
Complete the final chapter with Bethany.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete ??? with Bethany.
Kids shouldn't believe in fortunes...
Complete the final chapter with Eve.
Complete the final chapter with the Forgotten.
Complete the Corpse with Judas.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with Cain.
Complete the Corpse with Azazel.
Get that song out of her head.
Complete the Corpse with Magdalene.
Complete the final chapter with Judas.
Complete the final chapter with Magdalene.
Complete the final chapter with Isaac.
Complete the final chapter with Azazel.
The other side is calling...
Defeat Baby Plum 10 times.
Complete the Corpse with Isaac.
You are just like your father...
Complete the Corpse with Cain.
Where could it lead to?
Defeat all bosses in the Mausoleum.
Make a new friend!
Enter the Corpse...
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Defeat all bosses in Downpour.
Beat Hard mode as Lazarus without losing a life
Spend 40+ pennies in a single shop.
Complete ??? 3 times.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Beat everything in Hard Mode as every character.