Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
111% now stop playing!
OMG!
Unlocked a new co-player baby.
Built him out of meat cubes.
Beat Chest or Dark Room without taking damage.
Donated 600 pennies to the shop.
Unlocked Challenge #11.
Unlocked Challenge #19.
Unlocked a new boss!
New boss in the womb!
You became Lord of the Flies.
You are the best!!
New boss in the caves!
They are waiting.
New boss in the basement!
Isaac now holds the D6!
Donated 200 pennies to the shop.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
New boss in the depths!
Unlocked Challenge #9.
Donated 100 pennies to the shop.
The game just got harder!
Beat womb without taking damage.
Unlocked Challenge #6.
Beat depths without taking damage.
Unlocked another miniboss!
Beat caves without taking damage.
Unlocked Challenge #8.
Donated 20 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Unlocked Challenge #5.
Unlocked Challenge #10.
Beat basement without taking damage.
Destroy 100 rocks.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked a new item
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
Beat everything in Hard Mode as every character.
Complete the Corpse with the Lost.
Beat everything in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Apollyon.
Complete the Corpse with the Forgotten.
Complete the final chapter with Lazarus.
Complete the Corpse with Cain.
Complete the Corpse with Apollyon.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with Keeper.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Make a new friend!
Complete the final chapter with Eve.
Beat Greedier mode with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Bethany.
Beat the Void with Bethany.
Complete ??? with Bethany.
Complete the Corpse with Samson.
Complete the final chapter with Eden.
They will charge you up... for a small fee.
Complete the final chapter with Bethany.
Complete the final chapter with the Forgotten.
Complete the final chapter with ???.
Complete the final chapter with Azazel.
Complete the Corpse with Eve.
Complete Boss Rush with Bethany.
Complete the Corpse with Lilith.
Complete the final chapter with Magdalene.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete the Corpse with Eden.
Complete the Corpse with Judas.
Complete the final chapter with the Lost.
Complete the final chapter with Lilith.
Complete the final chapter with Isaac.
Kids shouldn't believe in fortunes...
Complete the Corpse with Lazarus.
Obtain 99 pennies. Then spend every single one of them.
Complete the Corpse with ???.
Complete the final chapter with Samson.
Complete the final chapter with Judas.
Defeat Baby Plum 10 times.
Complete the final chapter with Keeper.
Complete the Corpse with Magdalene.
Complete the Corpse with Azazel.
Kill 10 Battery Bums.
Complete the final chapter with Cain.
The other side is calling...
Kill Hornfel before he escapes!
You are just like your father...
Where could it lead to?
Complete the Corpse with Isaac.
Get that song out of her head.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Spend 40+ pennies in a single shop.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Enter the Corpse...
Beat Hard mode as Lazarus without losing a life
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Complete ??? 3 times.