Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
OMG!
Beat Chest or Dark Room without taking damage.
111% now stop playing!
Built him out of meat cubes.
Donated 600 pennies to the shop.
Unlocked Challenge #11.
Unlocked a new co-player baby.
New boss in the womb!
Unlocked a new boss!
New boss in the caves!
New boss in the basement!
You became Lord of the Flies.
Isaac now holds the D6!
You are the best!!
New boss in the depths!
Unlocked Challenge #19.
Donated 200 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
They are waiting.
Unlocked Challenge #9.
Beat depths without taking damage.
The game just got harder!
Beat womb without taking damage.
Donated 100 pennies to the shop.
Unlocked another miniboss!
Unlocked Challenge #6.
Unlocked Challenge #8.
Beat basement without taking damage.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Destroy 100 rocks.
Beat caves without taking damage.
Donated 20 pennies to the shop.
Unlocked a new item
Unlocked a new starting item.
Unlocked Challenge #24.
Unlocked a secret.
Greed just got harder!
Unlocked...
Nerd x 1000000
Unlocked a hidden chapter.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked Challenge #21.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
They will charge you up... for a small fee.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Beat Greed mode with Jacob and Esau.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Bethany.
Complete the Corpse with Bethany.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the final chapter with Apollyon.
Complete the Corpse with Apollyon.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the final chapter with Eden.
Complete the Corpse with Lazarus.
Complete the Corpse with Eden.
Complete the final chapter with Lazarus.
Complete the Corpse with Samson.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with ???.
Complete the final chapter with ???.
Complete the final chapter with Jacob and Esau.
Defeat Mega Satan with Bethany.
Complete ??? with Bethany.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Judas.
Complete the Corpse with Judas.
Complete the Corpse with Cain.
Complete the final chapter with Magdalene.
Complete the Corpse with Magdalene.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Complete the final chapter with Isaac.
Complete the Corpse with Isaac.
Get that song out of her head.
Complete the final chapter with Samson.
Kill 10 Battery Bums.
Complete the final chapter with Cain.
Kids shouldn't believe in fortunes...
Complete the final chapter with Azazel.
Beat the game in Hard mode with Jacob and Esau.
Obtain 99 pennies. Then spend every single one of them.
Make a new friend!
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Beat the game in Hard mode with Bethany.
Defeat all bosses in the Mines.
The other side is calling...
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Kill Hornfel before he escapes!
Beat the Void with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete Boss Rush with Bethany.
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Defeat Baby Plum 10 times.
Spend 40+ pennies in a single shop.
Defeat all bosses in Downpour.
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.