Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
OMG!
111% now stop playing!
Unlocked a new co-player baby.
Built him out of meat cubes.
Unlocked Challenge #11.
Donated 600 pennies to the shop.
Unlocked Challenge #8.
Unlocked a new character.
New mode unlocked!
You became Lord of the Flies.
Donated 200 pennies to the shop.
Unlocked even more bosses!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked new enemies!
New boss in the womb!
Unlocked Challenge #19.
Isaac now holds the D6!
You are the best!!
Beat Chest or Dark Room without taking damage.
They are waiting.
New boss in the basement!
Beat depths without taking damage.
New boss in the caves!
New boss in the depths!
Your future's past waits.
Unlocked a new boss!
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #9.
Beat womb without taking damage.
Unlocked another miniboss!
Donated 100 pennies to the shop.
The game just got harder!
Beat caves without taking damage.
Donated 20 pennies to the shop.
Unlocked Challenge #6.
Destroy 100 rocks.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Unlocked Challenge #5.
Unlocked Challenge #10.
Beat basement without taking damage.
Nerd x 1000000
Unlocked...
Unlocked Challenge #24.
Unlocked a new item
Unlocked a new starting item.
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
Beat the game in Hard mode with Jacob and Esau.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Beat the game in Hard mode with Bethany.
Complete the final chapter with Eden.
Complete the Corpse with Eden.
Beat Greed mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Corpse with ???.
Complete the Corpse with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the final chapter with ???.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Complete the Corpse with Apollyon.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Complete the final chapter with Apollyon.
Complete the Corpse with Lilith.
Complete the Corpse with Cain.
Make a new friend!
Complete the Corpse with Samson.
Complete the final chapter with Cain.
Kids shouldn't believe in fortunes...
Complete the Corpse with Isaac.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the final chapter with Eve.
Complete the final chapter with Azazel.
Beat Greed mode with Bethany.
Complete the Corpse with Judas.
Complete the Corpse with Eve.
Get that song out of her head.
Complete the Corpse with Keeper.
Complete the Corpse with the Lost.
Obtain 99 pennies. Then spend every single one of them.
Complete the final chapter with the Lost.
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Complete the Corpse with Azazel.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Defeat all bosses in the Mausoleum.
Defeat all bosses in Downpour.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete the Corpse with Bethany.
Defeat Baby Plum 10 times.
Complete the final chapter with Samson.
Complete the final chapter with Bethany.
Complete the final chapter with Lilith.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete the final chapter with Isaac.
Complete the final chapter with Judas.
Complete the final chapter with the Forgotten.
Complete the final chapter with Keeper.
The other side is calling...
Spend 40+ pennies in a single shop.
You are just like your father...
Where could it lead to?
Complete the Corpse with the Forgotten.
Enter the Corpse...
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
They will charge you up... for a small fee.
Kill 10 Battery Bums.
Beat everything in Hard Mode as every character.