Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Unlocked new enemies!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
111% now stop playing!
OMG!
Unlocked a new co-player baby.
Unlocked Challenge #11.
New boss in the womb!
You are the best!!
Isaac now holds the D6!
Built him out of meat cubes.
Unlocked Challenge #19.
Unlocked a new boss!
Beat Chest or Dark Room without taking damage.
They are waiting.
New boss in the caves!
New boss in the depths!
Beat womb without taking damage.
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
Donated 600 pennies to the shop.
Unlocked Challenge #9.
New boss in the basement!
Donated 200 pennies to the shop.
Beat depths without taking damage.
You became Lord of the Flies.
Beat caves without taking damage.
Unlocked another miniboss!
The game just got harder!
Donated 100 pennies to the shop.
Unlocked Challenge #6.
Beat basement without taking damage.
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked Challenge #8.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Donated 20 pennies to the shop.
Destroy 100 rocks.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Unlocked Challenge #24.
Greed just got harder!
Unlocked a secret.
Unlocked Challenge #27.
Unlocked Challenge #26.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Beat everything in Hard mode with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Corpse with Lilith.
Complete the Corpse with Lazarus.
Complete the Corpse with Eve.
Complete the Corpse with Cain.
Make a new friend!
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Complete ??? with Bethany.
Complete the final chapter with Eden.
Complete the final chapter with ???.
Complete the Corpse with ???.
Complete the final chapter with Magdalene.
Complete the Corpse with Magdalene.
Get that song out of her head.
Complete the final chapter with Eve.
Complete the final chapter with Lilith.
Complete the final chapter with Keeper.
Complete the final chapter with the Forgotten.
Complete the Corpse with the Forgotten.
Complete the Corpse with Keeper.
Complete the final chapter with Samson.
Complete the Corpse with Samson.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Kill 10 Battery Bums.
Complete ??? with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the Corpse with Eden.
Complete the final chapter with Cain.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Complete the final chapter with Azazel.
Complete the Corpse with Azazel.
They will charge you up... for a small fee.
Complete the final chapter with Judas.
Complete the Corpse with Judas.
Beat Greedier mode with Bethany.
Beat Greed mode with Bethany.
Kids shouldn't believe in fortunes...
Obtain 99 pennies. Then spend every single one of them.
Complete the Corpse with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete Boss Rush with Bethany.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Complete the final chapter with Lazarus.
Complete the final chapter with Isaac.
Spend 40+ pennies in a single shop.
Defeat Baby Plum 10 times.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
The other side is calling...
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Enter the Corpse...
Kill Hornfel before he escapes!
Complete ??? 3 times.