Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
111% now stop playing!
OMG!
Unlocked a new item.
New mode unlocked!
Unlocked a new character.
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
Unlocked a new co-player baby.
Beat depths without taking damage.
Built him out of meat cubes.
You became Lord of the Flies.
Beat Chest or Dark Room without taking damage.
Donated 600 pennies to the shop.
New boss in the womb!
Unlocked Challenge #11.
New boss in the caves!
New boss in the basement!
You are the best!!
Unlocked a new boss!
Unlocked Challenge #19.
Isaac now holds the D6!
Beat womb without taking damage.
Beat caves without taking damage.
New boss in the depths!
They are waiting.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Donated 200 pennies to the shop.
Unlocked Challenge #9.
The game just got harder!
Unlocked another miniboss!
Donated 100 pennies to the shop.
Unlocked Challenge #6.
Unlocked Challenge #8.
Donated 20 pennies to the shop.
Beat basement without taking damage.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked Challenge #21.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Corpse with Jacob and Esau.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Bethany.
Complete ??? with Jacob and Esau.
Complete the final chapter with Bethany.
Complete the Chest with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the final chapter with the Forgotten.
Complete the Corpse with the Forgotten.
Complete the Cathedral with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete the Corpse with Keeper.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the final chapter with Jacob and Esau.
Beat the Void with Bethany.
They will charge you up... for a small fee.
Beat the game in Hard mode with Jacob and Esau.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the Corpse with the Lost.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Complete the final chapter with the Lost.
Complete the Corpse with Eden.
Complete the final chapter with Samson.
Complete the Corpse with Samson.
Complete the Corpse with Eve.
Kids shouldn't believe in fortunes...
Complete the final chapter with Eden.
Kill 10 Battery Bums.
Complete the final chapter with Eve.
Beat Greedier mode with Bethany.
Beat Greed mode with Bethany.
Complete the Corpse with Judas.
Complete the final chapter with Judas.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Complete the final chapter with Magdalene.
Complete the Corpse with Magdalene.
Complete the Corpse with Cain.
Make a new friend!
Complete the final chapter with Cain.
Complete the final chapter with Keeper.
Obtain 99 pennies. Then spend every single one of them.
Complete the Corpse with ???.
Defeat Baby Plum 10 times.
Complete the Corpse with Isaac.
Complete the final chapter with Isaac.
Complete the final chapter with Azazel.
Complete the final chapter with ???.
The other side is calling...
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Beat the game in Hard mode with Bethany.
You are just like your father...
Where could it lead to?
Complete the Corpse with Azazel.
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Spend 40+ pennies in a single shop.
Defeat all bosses in Downpour.
Beat Hard mode as Lazarus without losing a life
Get that song out of her head.
Kill Hornfel before he escapes!
Complete ??? 3 times.