Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
OMG!
111% now stop playing!
Unlocked a new item.
Unlocked even more bosses!
Unlocked a new co-player baby.
Unlocked new bosses!
New boss in the womb!
Donated 600 pennies to the shop.
Unlocked a new character.
Alt stage to the womb.
New mode unlocked!
New boss in the basement!
Unlocked Challenge #11.
Built him out of meat cubes.
You are the best!!
New boss in the caves!
Alt stage to the depths.
You became Lord of the Flies.
Isaac now holds the D6!
Alt stage to the caves.
Donated 200 pennies to the shop.
New boss in the depths!
Unlocked a new boss!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #19.
Alt stage to the basement.
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked Challenge #9.
Donated 100 pennies to the shop.
Beat Chest or Dark Room without taking damage.
They are waiting.
Unlocked new enemies!
The game just got harder!
Unlocked another miniboss!
Beat basement without taking damage.
Beat depths without taking damage.
Beat caves without taking damage.
Unlocked Challenge #6.
Unlocked Challenge #8.
Beat womb without taking damage.
Destroy 100 rocks.
Donated 20 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Unlocked Challenge #24.
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new challenge.
Unlocked a new area.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the Corpse with Samson.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Bethany.
Complete the final chapter with Lilith.
Complete the Corpse with Lazarus.
Complete the final chapter with Eve.
Complete the final chapter with Eden.
Complete the final chapter with Isaac.
Kids shouldn't believe in fortunes...
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Apollyon.
Complete the final chapter with Samson.
Obtain 99 pennies. Then spend every single one of them.
Complete the final chapter with Azazel.
Complete the final chapter with Lazarus.
Complete the Corpse with ???.
Complete the final chapter with ???.
Complete the final chapter with the Forgotten.
Kill 10 Battery Bums.
Complete the final chapter with Magdalene.
Complete the Corpse with Isaac.
Complete the final chapter with Cain.
Complete the Corpse with Magdalene.
Complete the Corpse with Eve.
Complete the Corpse with Apollyon.
Complete the Corpse with the Forgotten.
Complete the Corpse with Cain.
Complete the final chapter with Judas.
Defeat Baby Plum 10 times.
The other side is calling...
Complete the Corpse with Eden.
Complete the Corpse with Judas.
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Spend 40+ pennies in a single shop.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Defeat all bosses in the Mines.
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Kill Hornfel before he escapes!
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Defeat all bosses in Downpour.
Beat Hard mode as Lazarus without losing a life
Get that song out of her head.
Complete ??? 3 times.
Make a new friend!
Complete the Cathedral with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Lilith.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
They will charge you up... for a small fee.
Beat everything in Hard Mode as every character.