Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
111% now stop playing!
OMG!
Unlocked a new co-player baby.
Built him out of meat cubes.
Beat depths without taking damage.
Beat caves without taking damage.
Beat womb without taking damage.
Donated 600 pennies to the shop.
Unlocked Challenge #11.
Beat Chest or Dark Room without taking damage.
You became Lord of the Flies.
New boss in the womb!
Donated 200 pennies to the shop.
New boss in the basement!
Unlocked a new boss!
Unlocked Challenge #19.
New boss in the caves!
You are the best!!
Isaac now holds the D6!
They are waiting.
New boss in the depths!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Donated 100 pennies to the shop.
Unlocked Challenge #9.
Unlocked another miniboss!
The game just got harder!
Beat basement without taking damage.
Unlocked Challenge #6.
Donated 20 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Unlocked Challenge #8.
Destroy 100 rocks.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked Challenge #21.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Beat everything in Hard mode with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the Corpse with Apollyon.
They will charge you up... for a small fee.
Complete the final chapter with Apollyon.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the Corpse with the Lost.
Complete the Chest with Jacob and Esau.
Complete the final chapter with the Lost.
Complete the Corpse with Eden.
Get that song out of her head.
Complete the final chapter with Eden.
Complete the Corpse with Lazarus.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the Corpse with Eve.
Make a new friend!
Kill 10 Battery Bums.
Complete the final chapter with Eve.
Complete the Corpse with ???.
Complete the final chapter with ???.
Complete the Corpse with Judas.
Complete the final chapter with Judas.
Complete the Corpse with Cain.
Complete the final chapter with Cain.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Complete the final chapter with Azazel.
Complete the Corpse with Azazel.
Complete the final chapter with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete ??? with Jacob and Esau.
Defeat Baby Plum 10 times.
Complete the Cathedral with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Bethany.
Defeat all bosses in the Mausoleum.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete Boss Rush with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete ??? with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Complete the final chapter with Lazarus.
Obtain 99 pennies. Then spend every single one of them.
Complete the final chapter with Isaac.
The other side is calling...
Kids shouldn't believe in fortunes...
You are just like your father...
Where could it lead to?
Complete the Corpse with Isaac.
Spend 40+ pennies in a single shop.
Enter the Corpse...
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Complete ??? 3 times.