Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
Unlocked a new character.
111% now stop playing!
OMG!
Built him out of meat cubes.
Unlocked a new co-player baby.
Beat Chest or Dark Room without taking damage.
New boss in the womb!
Unlocked Challenge #11.
Donated 600 pennies to the shop.
Unlocked Challenge #19.
Unlocked a new boss!
You are the best!!
They are waiting.
Beat depths without taking damage.
New boss in the depths!
Isaac now holds the D6!
New boss in the caves!
New boss in the basement!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Beat womb without taking damage.
Unlocked Challenge #9.
You became Lord of the Flies.
Donated 200 pennies to the shop.
The game just got harder!
Beat caves without taking damage.
Unlocked Challenge #6.
Unlocked another miniboss!
Donated 100 pennies to the shop.
Beat basement without taking damage.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
Unlocked Challenge #8.
Donated 20 pennies to the shop.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Nerd x 1000000
Unlocked a new starting item.
Unlocked...
Unlocked a secret.
Greed just got harder!
Unlocked a new item
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new challenge.
Unlocked a new area.
Beat everything in Hard Mode as every character.
Complete the final chapter with Isaac.
Complete the final chapter with Eve.
Complete the final chapter with Samson.
Complete the final chapter with Lazarus.
Complete the final chapter with Apollyon.
Complete the final chapter with Lilith.
Complete the final chapter with the Lost.
Complete the final chapter with Magdalene.
Complete the final chapter with Keeper.
Complete the final chapter with Eden.
Complete the Corpse with Eden.
Kill 10 Battery Bums.
Beat everything in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Complete the final chapter with Azazel.
Complete the final chapter with the Forgotten.
Complete the final chapter with ???.
Complete the final chapter with Judas.
Complete the final chapter with Cain.
Complete the Corpse with the Lost.
Complete the Corpse with Lilith.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete the Corpse with Keeper.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with Apollyon.
Complete the Corpse with the Forgotten.
Complete the Corpse with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Kids shouldn't believe in fortunes...
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Corpse with Lazarus.
Complete the Corpse with Samson.
Complete the Corpse with Eve.
They will charge you up... for a small fee.
Complete the Corpse with Azazel.
The other side is calling...
Complete the Corpse with ???.
Complete the Corpse with Judas.
Complete the Corpse with Bethany.
Complete the Corpse with Cain.
Make a new friend!
Complete the Corpse with Magdalene.
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Enter the Corpse...
Defeat all bosses in the Mines.
Get that song out of her head.
Defeat all bosses in the Mausoleum.
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Beat the Void with Bethany.
Defeat Baby Plum 10 times.
Complete ??? with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Obtain 99 pennies. Then spend every single one of them.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Complete Boss Rush with Bethany.
Beat Greedier mode with Bethany.
Beat Greed mode with Bethany.
Spend 40+ pennies in a single shop.
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.