Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
New mode unlocked!
Unlocked new enemies!
Alt stage to the basement.
OMG!
111% now stop playing!
Built him out of meat cubes.
Unlocked a new co-player baby.
Unlocked a new boss!
Donated 600 pennies to the shop.
You became Lord of the Flies.
New boss in the womb!
New boss in the caves!
New boss in the basement!
You are the best!!
Isaac now holds the D6!
Beat caves without taking damage.
Unlocked Challenge #11.
Beat womb without taking damage.
Unlocked Challenge #19.
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
New boss in the depths!
Beat basement without taking damage.
Beat Chest or Dark Room without taking damage.
They are waiting.
Unlocked Challenge #9.
Donated 200 pennies to the shop.
Unlocked Challenge #8.
The game just got harder!
Beat depths without taking damage.
Unlocked Challenge #6.
Donated 100 pennies to the shop.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Unlocked another miniboss!
Donated 20 pennies to the shop.
Destroy 100 rocks.
Unlocked Challenge #5.
Unlocked Challenge #10.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #27.
Unlocked a new item
Unlocked Challenge #24.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #26.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
They will charge you up... for a small fee.
Beat everything in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the final chapter with Samson.
Complete the Corpse with the Lost.
Complete the final chapter with Keeper.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with Lilith.
Complete the Corpse with the Forgotten.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Bethany.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the final chapter with Apollyon.
Complete the Corpse with Keeper.
Complete the final chapter with Lilith.
Complete the final chapter with Eve.
Complete the final chapter with Judas.
Complete the Corpse with Jacob and Esau.
Kids shouldn't believe in fortunes...
Complete the final chapter with the Lost.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Complete the final chapter with Lazarus.
Complete the Corpse with Samson.
Kill 10 Battery Bums.
Complete the Corpse with Judas.
Complete the Corpse with Cain.
Complete the final chapter with Magdalene.
Beat Greedier mode with Bethany.
Beat Greed mode with Jacob and Esau.
Beat Greed mode with Bethany.
Complete the Corpse with Magdalene.
Complete the Corpse with Eden.
Complete the final chapter with Eden.
Complete the final chapter with Bethany.
Defeat Baby Plum 10 times.
Complete the Corpse with Lazarus.
Complete the Corpse with Apollyon.
Complete the Corpse with Eve.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the Corpse with Azazel.
Kill Hornfel before he escapes!
Make a new friend!
Complete the final chapter with the Forgotten.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Beat the game in Hard mode with Bethany.
Complete the final chapter with Cain.
Complete the final chapter with Azazel.
Complete the Corpse with ???.
Complete the final chapter with ???.
Complete the final chapter with Isaac.
The other side is calling...
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Enter the Corpse...
Defeat all bosses in Downpour.
Get that song out of her head.
Complete ??? 3 times.
Beat Hard mode as Lazarus without losing a life
Obtain 99 pennies. Then spend every single one of them.
Spend 40+ pennies in a single shop.