Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
OMG!
111% now stop playing!
Built him out of meat cubes.
Beat Chest or Dark Room without taking damage.
Unlocked a new co-player baby.
Beat depths without taking damage.
Donated 600 pennies to the shop.
Beat womb without taking damage.
New boss in the womb!
Unlocked Challenge #11.
You are the best!!
You became Lord of the Flies.
Unlocked Challenge #19.
Isaac now holds the D6!
They are waiting.
Unlocked Challenge #8.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
New boss in the depths!
Unlocked a new boss!
Donated 200 pennies to the shop.
New boss in the caves!
Unlocked Challenge #9.
Beat caves without taking damage.
New boss in the basement!
The game just got harder!
Unlocked Challenge #6.
Unlocked another miniboss!
Donated 100 pennies to the shop.
Destroy 100 rocks.
Unlocked Challenge #5.
Unlocked Challenge #10.
Beat basement without taking damage.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Donated 20 pennies to the shop.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
Beat everything in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Corpse with Jacob and Esau.
Complete the Corpse with Keeper.
Complete the Corpse with Lilith.
Complete the Corpse with Apollyon.
Complete the Corpse with the Lost.
Complete the Corpse with ???.
Complete the Corpse with the Forgotten.
Complete the Corpse with Eve.
Complete the Corpse with Samson.
Complete the Corpse with Lazarus.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Bethany.
Complete the Corpse with Judas.
Complete the Corpse with Cain.
Complete the Corpse with Eden.
Kill 10 Battery Bums.
Complete the Corpse with Azazel.
Make a new friend!
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Dark Room with Bethany.
Complete ??? with Bethany.
Complete the final chapter with Bethany.
Complete the final chapter with the Forgotten.
Complete the final chapter with Eden.
Complete the final chapter with the Lost.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with Apollyon.
Complete the final chapter with Keeper.
They will charge you up... for a small fee.
Complete the final chapter with Lilith.
Complete the final chapter with Lazarus.
Complete the final chapter with Azazel.
Complete the final chapter with Samson.
Complete the final chapter with Eve.
Obtain 99 pennies. Then spend every single one of them.
Complete the final chapter with ???.
Complete the final chapter with Cain.
Complete the final chapter with Isaac.
Complete the final chapter with Judas.
Complete the final chapter with Magdalene.
Defeat Baby Plum 10 times.
Get that song out of her head.
Complete the Corpse with Magdalene.
Beat Greed mode with Jacob and Esau.
The other side is calling...
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Enter the Corpse...
Kids shouldn't believe in fortunes...
Defeat all bosses in the Mines.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Defeat all bosses in the Mausoleum.
Complete Sheol with Bethany.
Complete Boss Rush with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Defeat all bosses in Downpour.
Beat Greedier mode with Bethany.
Beat Greed mode with Bethany.
Spend 40+ pennies in a single shop.
Beat Hard mode as Lazarus without losing a life
Kill Hornfel before he escapes!
Complete ??? 3 times.