Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Alt stage to the womb.
New mode unlocked!
Unlocked a new co-player baby.
Donated 600 pennies to the shop.
Built him out of meat cubes.
111% now stop playing!
Unlocked a new character.
OMG!
Unlocked Challenge #11.
Beat caves without taking damage.
Unlocked even more bosses!
Beat Chest or Dark Room without taking damage.
You became Lord of the Flies.
New boss in the womb!
Beat basement without taking damage.
Unlocked new bosses!
Alt stage to the depths.
You are the best!!
Alt stage to the basement.
Alt stage to the caves.
Unlocked new enemies!
Unlocked a new boss!
New boss in the caves!
Donated 200 pennies to the shop.
Isaac now holds the D6!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #19.
They are waiting.
New boss in the depths!
New boss in the basement!
Unlocked Challenge #9.
Beat womb without taking damage.
Donated 100 pennies to the shop.
The game just got harder!
Unlocked Challenge #6.
Beat depths without taking damage.
Donated 20 pennies to the shop.
Unlocked another miniboss!
Unlocked Challenge #8.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
Unlocked...
Unlocked a new starting item.
Unlocked a secret.
Greed just got harder!
Nerd x 1000000
Unlocked a new item
Unlocked Challenge #24.
Unlocked a hidden chapter.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked Challenge #21.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
Complete the Corpse with Judas.
Complete the final chapter with Eve.
Complete the final chapter with Cain.
Complete the final chapter with ???.
Complete the final chapter with Judas.
Complete the final chapter with the Forgotten.
Complete the final chapter with Eden.
Kill Hornfel before he escapes!
Defeat Baby Plum 10 times.
Obtain 99 pennies. Then spend every single one of them.
Complete the final chapter with Isaac.
Complete the final chapter with Lazarus.
Complete the final chapter with Bethany.
Complete the final chapter with Azazel.
Beat Greed mode with Bethany.
Defeat all bosses in Downpour.
Complete the Corpse with the Forgotten.
Complete the final chapter with Magdalene.
The other side is calling...
Complete the Corpse with Isaac.
Defeat all bosses in the Mines.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete Boss Rush with Bethany.
Kids shouldn't believe in fortunes...
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete ??? with Bethany.
You are just like your father...
Where could it lead to?
Complete the Corpse with Azazel.
Spend 40+ pennies in a single shop.
Beat Hard mode as Lazarus without losing a life
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Complete ??? 3 times.
Get that song out of her head.
Make a new friend!
Beat the game in Hard mode with Bethany.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Beat the game in Hard mode with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Magdalene.
Complete the Corpse with Cain.
Complete the Corpse with ???.
Complete the Corpse with Eve.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the Corpse with Lazarus.
Complete the Corpse with Eden.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the Corpse with Bethany.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
They will charge you up... for a small fee.
Kill 10 Battery Bums.
Beat everything in Hard Mode as every character.