Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
OMG!
111% now stop playing!
Unlocked a new item.
Built him out of meat cubes.
Unlocked a new co-player baby.
Unlocked a new character.
Unlocked Challenge #11.
Donated 600 pennies to the shop.
Unlocked even more bosses!
Alt stage to the womb.
Beat Chest or Dark Room without taking damage.
You are the best!!
Unlocked new enemies!
New boss in the womb!
Unlocked new bosses!
Donated 200 pennies to the shop.
Unlocked Challenge #19.
Unlocked a new boss!
New mode unlocked!
Beat womb without taking damage.
Alt stage to the depths.
Beat caves without taking damage.
Beat depths without taking damage.
Alt stage to the basement.
Alt stage to the caves.
They are waiting.
Donated 100 pennies to the shop.
Isaac now holds the D6!
You became Lord of the Flies.
New boss in the caves!
New boss in the basement!
New boss in the depths!
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
Unlocked Challenge #9.
Unlocked another miniboss!
Beat basement without taking damage.
The game just got harder!
Unlocked Challenge #8.
Unlocked Challenge #6.
Unlocked Challenge #5.
Unlocked Challenge #10.
Donated 20 pennies to the shop.
Destroy 100 rocks.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a secret.
Unlocked Challenge #26.
Greed just got harder!
Unlocked a new item
Unlocked a hidden chapter.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked Challenge #21.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked super special rocks.
Unlocked a new challenge.
They will charge you up... for a small fee.
Beat everything in Hard Mode as every character.
Beat everything in Hard mode with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete the Corpse with Apollyon.
Complete the final chapter with Bethany.
Complete the final chapter with the Forgotten.
Complete the Corpse with the Forgotten.
Complete the final chapter with Apollyon.
Complete the final chapter with Keeper.
Complete the Corpse with Lilith.
Complete the Corpse with Keeper.
Complete the final chapter with Lilith.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete the Corpse with Bethany.
Beat the Void with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Complete the final chapter with Eden.
Complete the Corpse with Eden.
Complete the final chapter with Lazarus.
Complete the Corpse with Lazarus.
Complete the final chapter with Samson.
Complete the Corpse with Samson.
Complete the final chapter with Eve.
Complete the Corpse with Eve.
Complete the final chapter with Azazel.
Complete the Chest with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Make a new friend!
Complete the final chapter with ???.
Complete the Corpse with ???.
Complete the final chapter with Judas.
Complete the final chapter with the Lost.
Defeat Baby Plum 10 times.
Complete the Corpse with Judas.
Complete the final chapter with Cain.
Complete the Corpse with Cain.
Complete the final chapter with Magdalene.
Complete the Corpse with the Lost.
Kill Hornfel before he escapes!
Defeat all bosses in the Mines.
Complete the Corpse with Magdalene.
Get that song out of her head.
Complete the final chapter with Isaac.
The other side is calling...
Kids shouldn't believe in fortunes...
Complete the Corpse with Isaac.
Defeat all bosses in the Mausoleum.
You are just like your father...
Where could it lead to?
Complete the Corpse with Azazel.
Enter the Corpse...
Defeat all bosses in Downpour.
Kill 10 Battery Bums.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Obtain 99 pennies. Then spend every single one of them.
Spend 40+ pennies in a single shop.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.