Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
111% now stop playing!
OMG!
Unlocked a new co-player baby.
Unlocked Challenge #11.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
Beat Chest or Dark Room without taking damage.
Isaac now holds the D6!
New boss in the womb!
You are the best!!
Unlocked Challenge #19.
They are waiting.
You became Lord of the Flies.
Donated 600 pennies to the shop.
Built him out of meat cubes.
Beat caves without taking damage.
Beat depths without taking damage.
Beat womb without taking damage.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked a new boss!
Unlocked Challenge #9.
New boss in the depths!
New boss in the caves!
The game just got harder!
Unlocked Challenge #6.
Unlocked Challenge #8.
Unlocked another miniboss!
Donated 200 pennies to the shop.
New boss in the basement!
Beat basement without taking damage.
Donated 100 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Unlocked Challenge #5.
Unlocked Challenge #10.
Donated 20 pennies to the shop.
Destroy 100 rocks.
Unlocked...
Nerd x 1000000
Unlocked a new starting item.
Unlocked a new item
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #24.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
They will charge you up... for a small fee.
Beat everything in Hard Mode as every character.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the Corpse with Eve.
Complete the Corpse with Keeper.
Complete the Corpse with Azazel.
Complete the Corpse with Apollyon.
Complete the final chapter with Lazarus.
Complete the Corpse with Lilith.
Complete the Corpse with Isaac.
Complete the Corpse with Magdalene.
Complete the final chapter with Cain.
Complete the final chapter with Azazel.
Complete the Corpse with Lazarus.
Complete the Corpse with Cain.
Complete the final chapter with the Forgotten.
Complete the Corpse with the Forgotten.
Beat everything in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Corpse with ???.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Eve.
Complete the final chapter with ???.
Complete the final chapter with Isaac.
Beat everything in Hard mode with Bethany.
Defeat Mega Satan with Bethany.
Complete the final chapter with Bethany.
Beat the Void with Bethany.
Complete ??? with Bethany.
Complete the Corpse with Bethany.
Complete the final chapter with Apollyon.
Complete the final chapter with Keeper.
Complete the final chapter with Magdalene.
Complete the final chapter with Judas.
Kill 10 Battery Bums.
Complete the Corpse with Judas.
Complete the Corpse with Samson.
Complete the final chapter with Lilith.
Complete Boss Rush with Bethany.
Complete the final chapter with Samson.
Complete the final chapter with Eden.
Kids shouldn't believe in fortunes...
Beat Greedier mode with Bethany.
Defeat Baby Plum 10 times.
The other side is calling...
You are just like your father...
Complete the Corpse with Eden.
Where could it lead to?
Obtain 99 pennies. Then spend every single one of them.
Kill Hornfel before he escapes!
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Defeat all bosses in the Mausoleum.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Make a new friend!
Enter the Corpse...
Get that song out of her head.
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Beat Greed mode with Bethany.
Spend 40+ pennies in a single shop.
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.